ParkinsonCanadaV1, Main, Exploration, bibRecord, 000747

Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

Identifieur interne : 000747 ( Main/Exploration ); précédent : 000746; suivant : 000748

Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

Auteurs : Karl Kieburtz [États-Unis] ; Barbara C. Tilley ; Jordan J. Elm ; Debra Babcock [États-Unis] ; Robert Hauser [États-Unis] ; G Webster Ross [États-Unis] ; Alicia H. Augustine [États-Unis] ; Erika U. Augustine [États-Unis] ; Michael J. Aminoff [États-Unis] ; Ivan G. Bodis-Wollner ; James Boyd ; Franca Cambi ; Kelvin Chou ; Chadwick W. Christine [États-Unis] ; Michelle Cines [États-Unis] ; Nabila Dahodwala [États-Unis] ; Lorelei Derwent [Canada] ; Richard B. Dewey ; Katherine Hawthorne [États-Unis] ; David J. Houghton [États-Unis] ; Cornelia Kamp [États-Unis] ; Maureen Leehey ; Mark F. Lew [États-Unis] ; Grace S Lin Liang [États-Unis] ; Sheng T. Luo ; Zoltan Mari [États-Unis] ; John C. Morgan ; Sotirios Parashos [États-Unis] ; Adriana Pérez ; Helen Petrovitch [États-Unis] ; Suja Rajan ; Sue Reichwein [États-Unis] ; Jessie Tatsuno Roth [États-Unis] ; Jay S. Schneider [États-Unis] ; Kathleen M. Shannon [États-Unis] ; David K. Simon [États-Unis] ; Tanya Simuni [États-Unis] ; Carlos Singer [États-Unis] ; Lewis Sudarsky [États-Unis] ; Caroline M. Tanner [États-Unis] ; Chizoba C. Umeh [États-Unis] ; Karen Williams [États-Unis] ; Anne-Marie Wills [États-Unis]

Source :

JAMA [ 1538-3598 ] ; 2015.

RBID : pubmed:25668262

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Creatine (adverse effects), Creatine (blood), Creatine (therapeutic use), Disease Progression, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Medication Adherence, Middle Aged, Parkinson Disease (drug therapy), Treatment Outcome.
MESH :
- chemical , adverse effects : Antiparkinson Agents, Creatine.
- chemical , blood : Creatine.
- chemical , therapeutic use : Antiparkinson Agents, Creatine.
- drug therapy : Parkinson Disease.
- Aged, Disease Progression, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Medication Adherence, Middle Aged, Treatment Outcome.

Abstract

There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.

DOI: 10.1001/jama.2015.120
PubMed: 25668262

Affiliations:

Le document en format XML

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<author><name sortKey="Bodis Wollner, Ivan G" sort="Bodis Wollner, Ivan G" uniqKey="Bodis Wollner I" first="Ivan G" last="Bodis-Wollner">Ivan G. Bodis-Wollner</name>
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<author><name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name>
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<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
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<author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name>
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<author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name>
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<author><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name>
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<author><name sortKey="Dahodwala, Nabila" sort="Dahodwala, Nabila" uniqKey="Dahodwala N" first="Nabila" last="Dahodwala">Nabila Dahodwala</name>
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<author><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B" last="Dewey">Richard B. Dewey</name>
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<author><name sortKey="Hawthorne, Katherine" sort="Hawthorne, Katherine" uniqKey="Hawthorne K" first="Katherine" last="Hawthorne">Katherine Hawthorne</name>
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<author><name sortKey="Houghton, David J" sort="Houghton, David J" uniqKey="Houghton D" first="David J" last="Houghton">David J. Houghton</name>
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<author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>University of Rochester, Rochester</wicri:cityArea>
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<author><name sortKey="Leehey, Maureen" sort="Leehey, Maureen" uniqKey="Leehey M" first="Maureen" last="Leehey">Maureen Leehey</name>
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<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
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<author><name sortKey="Liang, Grace S Lin" sort="Liang, Grace S Lin" uniqKey="Liang G" first="Grace S Lin" last="Liang">Grace S Lin Liang</name>
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<author><name sortKey="Luo, Sheng T" sort="Luo, Sheng T" uniqKey="Luo S" first="Sheng T" last="Luo">Sheng T. Luo</name>
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<author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
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<author><name sortKey="Morgan, John C" sort="Morgan, John C" uniqKey="Morgan J" first="John C" last="Morgan">John C. Morgan</name>
<affiliation><nlm:affiliation>Georgia Regents University, Augusta.</nlm:affiliation>
<wicri:noCountry code="subField">Augusta</wicri:noCountry>
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</author>
<author><name sortKey="Parashos, Sotirios" sort="Parashos, Sotirios" uniqKey="Parashos S" first="Sotirios" last="Parashos">Sotirios Parashos</name>
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</placeName>
<wicri:cityArea>Struthers Parkinson's Center, Golden Valley</wicri:cityArea>
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</author>
<author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name>
<affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation>
<wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
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<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rajan, Suja" sort="Rajan, Suja" uniqKey="Rajan S" first="Suja" last="Rajan">Suja Rajan</name>
<affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation>
<wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Reichwein, Sue" sort="Reichwein, Sue" uniqKey="Reichwein S" first="Sue" last="Reichwein">Sue Reichwein</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Roth, Jessie Tatsuno" sort="Roth, Jessie Tatsuno" uniqKey="Roth J" first="Jessie Tatsuno" last="Roth">Jessie Tatsuno Roth</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
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<placeName><settlement type="city">San Francisco</settlement>
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</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name>
<affiliation wicri:level="2"><nlm:affiliation>Thomas Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Thomas Jefferson University, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name>
<affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation>
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<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
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</author>
<author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name>
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<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
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<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sudarsky, Lewis" sort="Sudarsky, Lewis" uniqKey="Sudarsky L" first="Lewis" last="Sudarsky">Lewis Sudarsky</name>
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</placeName>
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<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
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<author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C" last="Umeh">Chizoba C. Umeh</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
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<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name>
<affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.</title>
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<affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
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<wicri:cityArea>University of Rochester, Rochester</wicri:cityArea>
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<author><name sortKey="Tilley, Barbara C" sort="Tilley, Barbara C" uniqKey="Tilley B" first="Barbara C" last="Tilley">Barbara C. Tilley</name>
<affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation>
<wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Elm, Jordan J" sort="Elm, Jordan J" uniqKey="Elm J" first="Jordan J" last="Elm">Jordan J. Elm</name>
<affiliation><nlm:affiliation>Medical University of South Carolina, Charleston.</nlm:affiliation>
<wicri:noCountry code="subField">Charleston</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Babcock, Debra" sort="Babcock, Debra" uniqKey="Babcock D" first="Debra" last="Babcock">Debra Babcock</name>
<affiliation wicri:level="2"><nlm:affiliation>National Institutes of Health, Bethesda, Maryland.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name>
<affiliation wicri:level="4"><nlm:affiliation>University of South Florida, Tampa.</nlm:affiliation>
<orgName type="university">Université de Floride du Sud</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Tampa</settlement>
<region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
<affiliation wicri:level="2"><nlm:affiliation>Pacific Health Research and Education Institute, Honolulu, Hawaii.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Augustine, Alicia H" sort="Augustine, Alicia H" uniqKey="Augustine A" first="Alicia H" last="Augustine">Alicia H. Augustine</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Augustine, Erika U" sort="Augustine, Erika U" uniqKey="Augustine E" first="Erika U" last="Augustine">Erika U. Augustine</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Aminoff, Michael J" sort="Aminoff, Michael J" uniqKey="Aminoff M" first="Michael J" last="Aminoff">Michael J. Aminoff</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Bodis Wollner, Ivan G" sort="Bodis Wollner, Ivan G" uniqKey="Bodis Wollner I" first="Ivan G" last="Bodis-Wollner">Ivan G. Bodis-Wollner</name>
<affiliation><nlm:affiliation>State University of New York Downstate Medical Center, Brooklyn.</nlm:affiliation>
<wicri:noCountry code="subField">Brooklyn</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name>
<affiliation><nlm:affiliation>University of Vermont, Burlington.</nlm:affiliation>
<wicri:noCountry code="subField">Burlington</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation><nlm:affiliation>University of Kentucky, Lexington.</nlm:affiliation>
<wicri:noCountry code="subField">Lexington</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name>
<affiliation><nlm:affiliation>University of Michigan, Ann Arbor.</nlm:affiliation>
<wicri:noCountry code="subField">Ann Arbor</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Maryland School of Medicine, Baltimore.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Baltimore</settlement>
<region type="state">Maryland</region>
</placeName>
<wicri:orgArea>University of Maryland School of Medicine</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Dahodwala, Nabila" sort="Dahodwala, Nabila" uniqKey="Dahodwala N" first="Nabila" last="Dahodwala">Nabila Dahodwala</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Calgary, Calgary, Alberta</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B" last="Dewey">Richard B. Dewey</name>
<affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas.</nlm:affiliation>
<wicri:noCountry code="subField">Dallas</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hawthorne, Katherine" sort="Hawthorne, Katherine" uniqKey="Hawthorne K" first="Katherine" last="Hawthorne">Katherine Hawthorne</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Southern California, Los Angeles.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of Southern California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Houghton, David J" sort="Houghton, David J" uniqKey="Houghton D" first="David J" last="Houghton">David J. Houghton</name>
<affiliation wicri:level="2"><nlm:affiliation>Ochsner Medical Center, New Orleans, Louisiana.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Louisiane</region>
</placeName>
<wicri:cityArea>Ochsner Medical Center, New Orleans</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Leehey, Maureen" sort="Leehey, Maureen" uniqKey="Leehey M" first="Maureen" last="Leehey">Maureen Leehey</name>
<affiliation><nlm:affiliation>University of Colorado Denver, Aurora.</nlm:affiliation>
<wicri:noCountry code="subField">Aurora</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Southern California, Los Angeles.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of Southern California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Liang, Grace S Lin" sort="Liang, Grace S Lin" uniqKey="Liang G" first="Grace S Lin" last="Liang">Grace S Lin Liang</name>
<affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Luo, Sheng T" sort="Luo, Sheng T" uniqKey="Luo S" first="Sheng T" last="Luo">Sheng T. Luo</name>
<affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation>
<wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
<affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins University, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Morgan, John C" sort="Morgan, John C" uniqKey="Morgan J" first="John C" last="Morgan">John C. Morgan</name>
<affiliation><nlm:affiliation>Georgia Regents University, Augusta.</nlm:affiliation>
<wicri:noCountry code="subField">Augusta</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Parashos, Sotirios" sort="Parashos, Sotirios" uniqKey="Parashos S" first="Sotirios" last="Parashos">Sotirios Parashos</name>
<affiliation wicri:level="2"><nlm:affiliation>Struthers Parkinson's Center, Golden Valley, Minnesota.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Struthers Parkinson's Center, Golden Valley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name>
<affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation>
<wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<affiliation wicri:level="2"><nlm:affiliation>Pacific Health Research and Education Institute, Honolulu, Hawaii.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
<wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rajan, Suja" sort="Rajan, Suja" uniqKey="Rajan S" first="Suja" last="Rajan">Suja Rajan</name>
<affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation>
<wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Reichwein, Sue" sort="Reichwein, Sue" uniqKey="Reichwein S" first="Sue" last="Reichwein">Sue Reichwein</name>
<affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Roth, Jessie Tatsuno" sort="Roth, Jessie Tatsuno" uniqKey="Roth J" first="Jessie Tatsuno" last="Roth">Jessie Tatsuno Roth</name>
<affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name>
<affiliation wicri:level="2"><nlm:affiliation>Thomas Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Thomas Jefferson University, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name>
<affiliation wicri:level="2"><nlm:affiliation>Rush University Medical Center, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name>
<affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name>
<affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Miami, Miami, Florida.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sudarsky, Lewis" sort="Sudarsky, Lewis" uniqKey="Sudarsky L" first="Lewis" last="Sudarsky">Lewis Sudarsky</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
<affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C" last="Umeh">Chizoba C. Umeh</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name>
<affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern University, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">JAMA</title>
<idno type="eISSN">1538-3598</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Creatine (adverse effects)</term>
<term>Creatine (blood)</term>
<term>Creatine (therapeutic use)</term>
<term>Disease Progression</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Medication Adherence</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Creatine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Creatine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Creatine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Disease Progression</term>
<term>Double-Blind Method</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Medication Adherence</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.</div>
</front>
</TEI>
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<orgName><li>Université de Calgary</li>
<li>Université de Floride du Sud</li>
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<tree><noCountry><name sortKey="Bodis Wollner, Ivan G" sort="Bodis Wollner, Ivan G" uniqKey="Bodis Wollner I" first="Ivan G" last="Bodis-Wollner">Ivan G. Bodis-Wollner</name>
<name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name>
<name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name>
<name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B" last="Dewey">Richard B. Dewey</name>
<name sortKey="Elm, Jordan J" sort="Elm, Jordan J" uniqKey="Elm J" first="Jordan J" last="Elm">Jordan J. Elm</name>
<name sortKey="Leehey, Maureen" sort="Leehey, Maureen" uniqKey="Leehey M" first="Maureen" last="Leehey">Maureen Leehey</name>
<name sortKey="Luo, Sheng T" sort="Luo, Sheng T" uniqKey="Luo S" first="Sheng T" last="Luo">Sheng T. Luo</name>
<name sortKey="Morgan, John C" sort="Morgan, John C" uniqKey="Morgan J" first="John C" last="Morgan">John C. Morgan</name>
<name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name>
<name sortKey="Rajan, Suja" sort="Rajan, Suja" uniqKey="Rajan S" first="Suja" last="Rajan">Suja Rajan</name>
<name sortKey="Tilley, Barbara C" sort="Tilley, Barbara C" uniqKey="Tilley B" first="Barbara C" last="Tilley">Barbara C. Tilley</name>
</noCountry>
<country name="États-Unis"><region name="État de New York"><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
</region>
<name sortKey="Aminoff, Michael J" sort="Aminoff, Michael J" uniqKey="Aminoff M" first="Michael J" last="Aminoff">Michael J. Aminoff</name>
<name sortKey="Augustine, Alicia H" sort="Augustine, Alicia H" uniqKey="Augustine A" first="Alicia H" last="Augustine">Alicia H. Augustine</name>
<name sortKey="Augustine, Erika U" sort="Augustine, Erika U" uniqKey="Augustine E" first="Erika U" last="Augustine">Erika U. Augustine</name>
<name sortKey="Babcock, Debra" sort="Babcock, Debra" uniqKey="Babcock D" first="Debra" last="Babcock">Debra Babcock</name>
<name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name>
<name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name>
<name sortKey="Dahodwala, Nabila" sort="Dahodwala, Nabila" uniqKey="Dahodwala N" first="Nabila" last="Dahodwala">Nabila Dahodwala</name>
<name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name>
<name sortKey="Hawthorne, Katherine" sort="Hawthorne, Katherine" uniqKey="Hawthorne K" first="Katherine" last="Hawthorne">Katherine Hawthorne</name>
<name sortKey="Houghton, David J" sort="Houghton, David J" uniqKey="Houghton D" first="David J" last="Houghton">David J. Houghton</name>
<name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name>
<name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
<name sortKey="Liang, Grace S Lin" sort="Liang, Grace S Lin" uniqKey="Liang G" first="Grace S Lin" last="Liang">Grace S Lin Liang</name>
<name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
<name sortKey="Parashos, Sotirios" sort="Parashos, Sotirios" uniqKey="Parashos S" first="Sotirios" last="Parashos">Sotirios Parashos</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Reichwein, Sue" sort="Reichwein, Sue" uniqKey="Reichwein S" first="Sue" last="Reichwein">Sue Reichwein</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name>
<name sortKey="Roth, Jessie Tatsuno" sort="Roth, Jessie Tatsuno" uniqKey="Roth J" first="Jessie Tatsuno" last="Roth">Jessie Tatsuno Roth</name>
<name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name>
<name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name>
<name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name>
<name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name>
<name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<name sortKey="Sudarsky, Lewis" sort="Sudarsky, Lewis" uniqKey="Sudarsky L" first="Lewis" last="Sudarsky">Lewis Sudarsky</name>
<name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
<name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C" last="Umeh">Chizoba C. Umeh</name>
<name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name>
<name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
</country>
<country name="Canada"><region name="Alberta"><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000747 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000747 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25668262
   |texte=   Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25668262" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.